Drug interactions
Vedolizumab + Yellow fever vaccine
Severity: Moderate
Vedolizumab and Yellow fever vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yellow fever vaccine is live attenuated and can rarely cause serious viscerotropic or neurotropic disease, with higher risk in immunocompromised patients. Vedolizumab is gut-selective, but labeling advises avoiding live vaccines unless benefit outweighs risk.
What this interaction means in plain words
Vedolizumab and Yellow fever vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical reduced immune control of live attenuated virus replication during vedolizumab therapy.
What to do
Avoid vaccination unless travel to an endemic area is unavoidable. If needed, weigh risk-benefit, or consider a medical exemption letter.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Vedolizumab with Yellow fever vaccine?
MediHelp rates the interaction as moderate. Vedolizumab and Yellow fever vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yellow fever vaccine is live attenuated and can rarely cause serious viscerotropic or neurotropic disease, with higher risk in immunocompromised patients. Vedolizumab is gut-selective, but labeling advises avoiding live vaccines unless benefit outweighs risk.
How serious is the interaction between Vedolizumab and Yellow fever vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination unless travel to an endemic area is unavoidable. If needed, weigh risk-benefit, or consider a medical exemption letter.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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