Drug interactions
Vedolizumab + Zoster vaccine live
Severity: Moderate
Vedolizumab and Zoster vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live zoster vaccine contains attenuated varicella-zoster virus. Vedolizumab's gut-selective action makes a significant systemic effect unlikely, but labeling advises caution with live vaccines because of possible vaccine-virus infection or reduced response.
What this interaction means in plain words
Vedolizumab and Zoster vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical reduced immune control of live attenuated virus during vedolizumab therapy.
What to do
Prefer the recombinant non-live zoster vaccine in patients on vedolizumab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Vedolizumab with Zoster vaccine live?
MediHelp rates the interaction as moderate. Vedolizumab and Zoster vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live zoster vaccine contains attenuated varicella-zoster virus. Vedolizumab's gut-selective action makes a significant systemic effect unlikely, but labeling advises caution with live vaccines because of possible vaccine-virus infection or reduced response.
How serious is the interaction between Vedolizumab and Zoster vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer the recombinant non-live zoster vaccine in patients on vedolizumab.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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