Drug interactions
Vedolizumab + Zoster vaccine recombinant
Severity: Minor
Vedolizumab and Zoster vaccine recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vedolizumab is gut-selective and is not expected to substantially impair responses to the non-live recombinant zoster vaccine. Any reduction in response is likely small.
What this interaction means in plain words
Vedolizumab and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible mild attenuation of vaccine response via integrin blockade; effect not well established.
What to do
Vaccinate according to standard recommendations without delaying vaccination or altering vedolizumab.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Vedolizumab with Zoster vaccine recombinant?
MediHelp rates the interaction as minor. Vedolizumab and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vedolizumab is gut-selective and is not expected to substantially impair responses to the non-live recombinant zoster vaccine. Any reduction in response is likely small.
How serious is the interaction between Vedolizumab and Zoster vaccine recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to standard recommendations without delaying vaccination or altering vedolizumab.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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