Drug interactions
Vemurafenib + Vincristine
Severity: Moderate
Vemurafenib and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-gp in vitro and may increase vincristine exposure. Evidence is limited, but neurotoxicity could be worsened.
What this interaction means in plain words
Vemurafenib and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vemurafenib belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Vemurafenib inhibits P-gp efflux, potentially raising vincristine levels.
What to do
Monitor for neuropathy and constipation. Consider reducing the vincristine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Vemurafenib with Vincristine?
MediHelp rates the interaction as moderate. Vemurafenib and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-gp in vitro and may increase vincristine exposure. Evidence is limited, but neurotoxicity could be worsened.
How serious is the interaction between Vemurafenib and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy and constipation. Consider reducing the vincristine dose if toxicity appears.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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