Drug interactions
Venetoclax + Warfarin
Severity: Moderate
Venetoclax and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venetoclax can increase warfarin exposure, raising INR and bleeding risk.
What this interaction means in plain words
Venetoclax and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Venetoclax belongs to Miscellaneous; Warfarin belongs to Cardiovascular.
Why it happens
Venetoclax may inhibit P-glycoprotein and displace or alter warfarin handling, increasing warfarin concentrations.
What to do
Monitor INR more frequently after starting or changing venetoclax and reduce the warfarin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Venetoclax with Warfarin?
MediHelp rates the interaction as moderate. Venetoclax and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venetoclax can increase warfarin exposure, raising INR and bleeding risk.
How serious is the interaction between Venetoclax and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently after starting or changing venetoclax and reduce the warfarin dose as needed.
What other medicines interact with Venetoclax?
MediHelp also lists interactions of Venetoclax with, for example, Clarithromycin, Itraconazole, Ketoconazole. The full list is on the Venetoclax page.
Full monographs, dosing and an interaction checker in the MediHelp app
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