Drug interactions
Verapamil + Vinblastine
Severity: Moderate
Verapamil and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase vinblastine exposure and cellular retention, potentially worsening myelosuppression and neurotoxicity. The combination has been studied experimentally to overcome drug resistance, with increased toxicity.
What this interaction means in plain words
Verapamil and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Verapamil belongs to Cardiovascular; Vinblastine belongs to Oncology.
Why it happens
Verapamil inhibits P-glycoprotein-mediated efflux of vinblastine (and CYP3A4 metabolism to a lesser degree).
What to do
Monitor blood counts and signs of neurotoxicity or constipation, and reduce the vinblastine dose if toxicity develops. Consider a non-interacting antihypertensive or antiarrhythmic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Vinblastine
Frequently asked questions
Can I take Verapamil with Vinblastine?
MediHelp rates the interaction as moderate. Verapamil and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may increase vinblastine exposure and cellular retention, potentially worsening myelosuppression and neurotoxicity. The combination has been studied experimentally to overcome drug resistance, with increased toxicity.
How serious is the interaction between Verapamil and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neurotoxicity or constipation, and reduce the vinblastine dose if toxicity develops. Consider a non-interacting antihypertensive or antiarrhythmic if feasible.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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