Drug interactions
Verapamil + Zafirlukast
Severity: Minor
Verapamil and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast may slightly reduce CYP3A4 clearance of verapamil, which could increase its blood pressure lowering and negative chronotropic effects. The effect is expected to be modest and is mainly theoretical.
What this interaction means in plain words
Verapamil and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Verapamil belongs to Cardiovascular; Zafirlukast belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4 by zafirlukast reduces verapamil metabolism.
What to do
Monitor heart rate and blood pressure when zafirlukast is started or stopped in a patient on verapamil. Reduce the verapamil dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Verapamil with Zafirlukast?
MediHelp rates the interaction as minor. Verapamil and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast may slightly reduce CYP3A4 clearance of verapamil, which could increase its blood pressure lowering and negative chronotropic effects. The effect is expected to be modest and is mainly theoretical.
How serious is the interaction between Verapamil and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when zafirlukast is started or stopped in a patient on verapamil. Reduce the verapamil dose if bradycardia or hypotension develops.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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