Drug interactions
Verapamil + Ziprasidone
Severity: Moderate
Verapamil and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is partly metabolised by CYP3A4, so verapamil may modestly raise its levels. Both drugs can affect cardiac conduction and ziprasidone prolongs the QT interval, so the combination adds to arrhythmia concern.
What this interaction means in plain words
Verapamil and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Verapamil belongs to Cardiovascular; Ziprasidone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by verapamil raises ziprasidone exposure, with additive effects on cardiac conduction and QT interval.
What to do
Obtain a baseline ECG and monitor the QTc and heart rate. Correct potassium and magnesium before and during therapy, and consider alternatives in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Verapamil with Ziprasidone?
MediHelp rates the interaction as moderate. Verapamil and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone is partly metabolised by CYP3A4, so verapamil may modestly raise its levels. Both drugs can affect cardiac conduction and ziprasidone prolongs the QT interval, so the combination adds to arrhythmia concern.
How serious is the interaction between Verapamil and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc and heart rate. Correct potassium and magnesium before and during therapy, and consider alternatives in patients with other QT risk factors.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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