Drug interactions
Vinblastine + Voxelotor
Severity: Major
Vinblastine and Voxelotor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can increase exposure to sensitive CYP3A4 substrates. Higher vinblastine levels could worsen myelosuppression and neurotoxicity.
What this interaction means in plain words
Vinblastine and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Vinblastine belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, reducing vinblastine metabolism.
What to do
Avoid coadministration if possible. If needed, monitor blood counts and neurotoxicity and consider reducing the vinblastine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinblastine
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Vinblastine with Voxelotor?
MediHelp rates the interaction as major. Vinblastine and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voxelotor can increase exposure to sensitive CYP3A4 substrates. Higher vinblastine levels could worsen myelosuppression and neurotoxicity.
How serious is the interaction between Vinblastine and Voxelotor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration if possible. If needed, monitor blood counts and neurotoxicity and consider reducing the vinblastine dose.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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