Drug interactions
Vinblastine + Zafirlukast
Severity: Minor
Vinblastine and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine is metabolized by CYP3A4 and has a narrow therapeutic index. Weak CYP3A4 inhibition by zafirlukast might modestly raise exposure, but no clinically significant interaction is documented.
What this interaction means in plain words
Vinblastine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Vinblastine belongs to Oncology; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak CYP3A4 inhibition by zafirlukast reducing vinblastine clearance.
What to do
No empiric dose change is needed. Monitor blood counts and neurotoxicity during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Vinblastine
Frequently asked questions
Can I take Vinblastine with Zafirlukast?
MediHelp rates the interaction as minor. Vinblastine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vinblastine is metabolized by CYP3A4 and has a narrow therapeutic index. Weak CYP3A4 inhibition by zafirlukast might modestly raise exposure, but no clinically significant interaction is documented.
How serious is the interaction between Vinblastine and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor blood counts and neurotoxicity during therapy.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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