Drug interactions
Vinblastine + Zidovudine
Severity: Moderate
Vinblastine and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause bone marrow suppression, so combining them may deepen neutropenia and anemia. Patients with HIV-related malignancies receiving chemotherapy are at particular risk.
What this interaction means in plain words
Vinblastine and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vinblastine belongs to Oncology; Zidovudine belongs to Anti Virals.
Why it happens
Additive myelosuppressive effects of the two drugs.
What to do
Monitor complete blood counts closely during therapy. Consider dose reduction or an alternative antiretroviral without marrow toxicity if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Vinblastine
Frequently asked questions
Can I take Vinblastine with Zidovudine?
MediHelp rates the interaction as moderate. Vinblastine and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause bone marrow suppression, so combining them may deepen neutropenia and anemia. Patients with HIV-related malignancies receiving chemotherapy are at particular risk.
How serious is the interaction between Vinblastine and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely during therapy. Consider dose reduction or an alternative antiretroviral without marrow toxicity if cytopenias develop.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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