Drug interactions
Vinorelbine + Voriconazole
Severity: Moderate
Vinorelbine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can raise vinorelbine concentrations, increasing the risk of neutropenia and neurotoxicity such as peripheral neuropathy and constipation or ileus. Strong azole inhibitors of CYP3A4 are expected to reduce vinca alkaloid clearance.
What this interaction means in plain words
Vinorelbine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vinorelbine belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of vinorelbine.
What to do
Monitor blood counts and neurological and bowel function closely, and reduce the vinorelbine dose if toxicity appears. Consider a non-azole antifungal where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Vinorelbine
Frequently asked questions
Can I take Vinorelbine with Voriconazole?
MediHelp rates the interaction as moderate. Vinorelbine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can raise vinorelbine concentrations, increasing the risk of neutropenia and neurotoxicity such as peripheral neuropathy and constipation or ileus. Strong azole inhibitors of CYP3A4 are expected to reduce vinca alkaloid clearance.
How serious is the interaction between Vinorelbine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurological and bowel function closely, and reduce the vinorelbine dose if toxicity appears. Consider a non-azole antifungal where feasible.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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