Drug interactions
Vorapaxar + Vortioxetine
Severity: Moderate
Vorapaxar and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine impairs platelet serotonin uptake and vorapaxar blocks platelet PAR-1 thrombin signaling, so together they can raise the risk of bleeding. Bleeding events may range from bruising to serious gastrointestinal or intracranial haemorrhage.
What this interaction means in plain words
Vorapaxar and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic impairment of platelet function through serotonin reuptake inhibition and PAR-1 antagonism.
What to do
Monitor for signs of bleeding and review the need for both agents, particularly if other antiplatelets or anticoagulants are also used. Avoid use in patients with a history of intracranial haemorrhage, in whom vorapaxar is contraindicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Vorapaxar with Vortioxetine?
MediHelp rates the interaction as moderate. Vorapaxar and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine impairs platelet serotonin uptake and vorapaxar blocks platelet PAR-1 thrombin signaling, so together they can raise the risk of bleeding. Bleeding events may range from bruising to serious gastrointestinal or intracranial haemorrhage.
How serious is the interaction between Vorapaxar and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and review the need for both agents, particularly if other antiplatelets or anticoagulants are also used. Avoid use in patients with a history of intracranial haemorrhage, in whom vorapaxar is contraindicated.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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