Drug interactions
Voriconazole + Zuranolone
Severity: Moderate
Voriconazole and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises zuranolone concentrations, which increases sedation, somnolence and impaired psychomotor function. Zuranolone labeling recommends a dose reduction with strong CYP3A4 inhibitors.
What this interaction means in plain words
Voriconazole and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Voriconazole belongs to Anti Fungals; Zuranolone belongs to Central Nervous System.
Why it happens
Strong CYP3A4 inhibition by voriconazole reduces zuranolone metabolism.
What to do
Reduce the zuranolone dose per labeling (for example to 30 mg daily from 50 mg) during voriconazole use. Counsel the patient on sedation and driving, and monitor for CNS depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Voriconazole with Zuranolone?
MediHelp rates the interaction as moderate. Voriconazole and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole raises zuranolone concentrations, which increases sedation, somnolence and impaired psychomotor function. Zuranolone labeling recommends a dose reduction with strong CYP3A4 inhibitors.
How serious is the interaction between Voriconazole and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the zuranolone dose per labeling (for example to 30 mg daily from 50 mg) during voriconazole use. Counsel the patient on sedation and driving, and monitor for CNS depression.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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