Drug interactions
Zafirlukast + Ziprasidone
Severity: Minor
Zafirlukast and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast is a weak in vitro CYP3A4 inhibitor, and ziprasidone is partly metabolised by CYP3A4. A clinically relevant rise in ziprasidone levels is unlikely.
What this interaction means in plain words
Zafirlukast and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Zafirlukast belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Theoretical weak CYP3A4 inhibition by zafirlukast reducing ziprasidone clearance.
What to do
No dose change is needed. Consider an ECG if other QT-prolonging risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Zafirlukast with Ziprasidone?
MediHelp rates the interaction as minor. Zafirlukast and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast is a weak in vitro CYP3A4 inhibitor, and ziprasidone is partly metabolised by CYP3A4. A clinically relevant rise in ziprasidone levels is unlikely.
How serious is the interaction between Zafirlukast and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Consider an ECG if other QT-prolonging risk factors are present.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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