تداخل‌های دارویی
Azathioprine + Trastuzumab deruxtecan
شدت: شدید
Azathioprine and Trastuzumab deruxtecan: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Trastuzumab deruxtecan commonly causes neutropenia, and azathioprine also suppresses marrow and immune function. Together they may increase the risk of severe neutropenia and infection.
معنای این تداخل به زبان ساده
Azathioprine and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Trastuzumab deruxtecan belongs to Oncology.
چرا رخ می‌دهد
Additive myelosuppression and immunosuppression from the cytotoxic topoisomerase I inhibitor payload and azathioprine's antimetabolite effect.
اقدام لازم
Monitor complete blood counts before each trastuzumab deruxtecan dose and watch for fever or infection. Consider reducing or stopping azathioprine if neutropenia develops.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Azathioprine و Trastuzumab deruxtecan، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine منع مصرف
- Azathioprine + Bcg vaccine live منع مصرف
- Azathioprine + Febuxostat منع مصرف
- Azathioprine + Influenza virus vaccine quadrivalent intranasal منع مصرف
- Azathioprine + Measles mumps and rubella vaccine منع مصرف
- Azathioprine + Measles mumps and rubella vaccine live منع مصرف
تداخلات دیگر Trastuzumab deruxtecan
پرسش‌های متداول
Can I take Azathioprine with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Azathioprine and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab deruxtecan commonly causes neutropenia, and azathioprine also suppresses marrow and immune function. Together they may increase the risk of severe neutropenia and infection.
How serious is the interaction between Azathioprine and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts before each trastuzumab deruxtecan dose and watch for fever or infection. Consider reducing or stopping azathioprine if neutropenia develops.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
