تداخل‌های دارویی
Cannabidiol + Flutamide
شدت: متوسط
Cannabidiol and Flutamide: moderate interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cannabidiol can both inhibit and induce CYP1A2 in vitro, and flutamide is activated to its hydroxy metabolite mainly through CYP1A2. The net effect on flutamide exposure and on its hepatotoxic metabolites is unpredictable. Both agents can independently raise liver enzymes.
معنای این تداخل به زبان ساده
Cannabidiol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Flutamide belongs to Endocrine.
چرا رخ می‌دهد
Cannabidiol has mixed inhibitory and inducing effects on CYP1A2, altering flutamide metabolism in an unpredictable direction.
اقدام لازم
Monitor liver function tests regularly, as both drugs can cause hepatotoxicity. Watch for changes in antiandrogen efficacy and adjust therapy accordingly.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cannabidiol و Flutamide، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Flutamide
تداخلات دیگر Cannabidiol
پرسش‌های متداول
Can I take Cannabidiol with Flutamide?
MediHelp rates the interaction as moderate. Cannabidiol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol can both inhibit and induce CYP1A2 in vitro, and flutamide is activated to its hydroxy metabolite mainly through CYP1A2. The net effect on flutamide exposure and on its hepatotoxic metabolites is unpredictable. Both agents can independently raise liver enzymes.
How serious is the interaction between Cannabidiol and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly, as both drugs can cause hepatotoxicity. Watch for changes in antiandrogen efficacy and adjust therapy accordingly.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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