تداخل‌های دارویی
Ozanimod + Rasagiline
شدت: منع مصرف
Ozanimod and Rasagiline: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Ozanimod is metabolised to active metabolites that inhibit MAO-B, so adding an MAO inhibitor may lead to hypertensive crisis or serotonin toxicity, and labeling contraindicates concurrent use. MAO-B inhibitors may also change exposure to ozanimod active metabolites.
معنای این تداخل به زبان ساده
Ozanimod and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
چرا رخ می‌دهد
MAO-B inhibition by rasagiline may reduce formation of ozanimod active metabolites and the combined MAO inhibition may cause excess monoamines.
اقدام لازم
Avoid the combination and consider alternative therapy for multiple sclerosis or Parkinson disease. Allow at least 14 days after stopping ozanimod before starting an MAO inhibitor.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Ozanimod و Rasagiline، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Rasagiline
- Atomoxetine + Rasagiline منع مصرف
- Brimonidine + Rasagiline منع مصرف
- Bupropion-naltrexone + Rasagiline منع مصرف
- Bupropion + Rasagiline منع مصرف
- Clomipramine + Rasagiline منع مصرف
- Desvenlafaxine + Rasagiline منع مصرف
تداخلات دیگر Ozanimod
- Isocarboxazid + Ozanimod منع مصرف
- Linezolid + Ozanimod منع مصرف
- Ozanimod + Phenelzine منع مصرف
- Ozanimod + Procarbazine منع مصرف
- Ozanimod + Safinamide منع مصرف
- Ozanimod + Tranylcypromine منع مصرف
پرسش‌های متداول
Can I take Ozanimod with Rasagiline?
MediHelp rates the interaction as contraindicated. Ozanimod and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod is metabolised to active metabolites that inhibit MAO-B, so adding an MAO inhibitor may lead to hypertensive crisis or serotonin toxicity, and labeling contraindicates concurrent use. MAO-B inhibitors may also change exposure to ozanimod active metabolites.
How serious is the interaction between Ozanimod and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider alternative therapy for multiple sclerosis or Parkinson disease. Allow at least 14 days after stopping ozanimod before starting an MAO inhibitor.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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