تداخل‌های دارویی
Ozanimod + Safinamide
شدت: منع مصرف
Ozanimod and Safinamide: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Ozanimod's active metabolites are formed partly via MAO-B, and inhibition may change exposure and could allow nonselective MAO inhibition. Hypertensive crisis is a theoretical risk, and the clinical interaction has not been fully studied.
معنای این تداخل به زبان ساده
Ozanimod and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
چرا رخ می‌دهد
MAO-B inhibition alters formation of ozanimod's active metabolites, which may also inhibit MAO, creating a risk of excess adrenergic stimulation.
اقدام لازم
Avoid concurrent use as per ozanimod labeling. Allow at least 14 days between stopping one and starting the other.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Ozanimod و Safinamide، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Safinamide
- Amitriptyline + Safinamide منع مصرف
- Amoxapine + Safinamide منع مصرف
- Amphetamine polistirex + Safinamide منع مصرف
- Clomipramine + Safinamide منع مصرف
- Cyclobenzaprine + Safinamide منع مصرف
- Desipramine + Safinamide منع مصرف
تداخلات دیگر Ozanimod
- Isocarboxazid + Ozanimod منع مصرف
- Linezolid + Ozanimod منع مصرف
- Ozanimod + Phenelzine منع مصرف
- Ozanimod + Procarbazine منع مصرف
- Ozanimod + Rasagiline منع مصرف
- Ozanimod + Tranylcypromine منع مصرف
پرسش‌های متداول
Can I take Ozanimod with Safinamide?
MediHelp rates the interaction as contraindicated. Ozanimod and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's active metabolites are formed partly via MAO-B, and inhibition may change exposure and could allow nonselective MAO inhibition. Hypertensive crisis is a theoretical risk, and the clinical interaction has not been fully studied.
How serious is the interaction between Ozanimod and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as per ozanimod labeling. Allow at least 14 days between stopping one and starting the other.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
