Référentiel des médicaments
Avelumab
Avelumab is a medicine in the class oncology. It is used for renal cell carcinoma.
- Classe médicamenteuse: Oncology
- Indications: renal cell carcinoma
Dernière mise à jour Sources: EMA SmPC
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L'essentiel
- Classe médicamenteuse
- Oncology
- Code ATC
- L01FF04
- Formes courantes
- injection
- Dosages courants
- 20 mg/ml
- Interactions connues
- 5 (Modérée: 4 · Mineure: 1)
- Noms commerciaux
- 3
- Pays et marchés
- 3
Indications
Mécanisme d'action
Human IgG1 monoclonal antibody against PD-L1. It blocks PD-L1 interaction with PD-1 and B7.1 receptors, removing suppression of cytotoxic CD8+ T-cells and restoring anti-tumour T-cell responses. It also induces NK cell-mediated tumour cell lysis via ADCC.
Posologie adulte habituelle (résumé de la notice)
Monotherapy (MCC; first-line maintenance UC): 800 mg IV over 60 minutes every 2 weeks until disease progression or unacceptable toxicity
Grossesse et allaitement
- Grossesse
- Unsafe Limited data; based on mechanism it could cause foetal harm including abortion or stillbirth. Not recommended during pregnancy unless the woman's condition requires treatment.
- Allaitement
- Unsafe Unknown if excreted in human milk; advised not to breast-feed during treatment and for at least 1 month after the last dose.
Effets indésirables signalés
- Fatigue
- Nausea
- Diarrhoea
- Constipation
- Decreased appetite
- Infusion-related reactions
Contre-indications
- Hypersensitivity to the active substance or to any excipient
Précautions particulières
- Infusion-related reactions can be severe; monitor for pyrexia, chills, flushing, hypotension, dyspnoea, wheezing, back pain, abdominal pain and urticaria.
- Immune-mediated adverse reactions (pneumonitis, hepatitis, colitis, pancreatitis, myocarditis, endocrinopathies, nephritis) may be severe or fatal; monitor, withhold and give corticosteroids according to severity.
- With axitinib, hepatotoxicity occurs with higher frequency of Grade 3 and 4 ALT/AST elevation; monitor liver function more frequently than with monotherapy.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (5)
- Avelumab + Cefadroxil Moderate
- Avelumab + Cefalexin Moderate
- Avelumab + Piperacillin Moderate
- Avelumab + Piperacillin-tazobactam Moderate
- Avelumab + Penicillin g Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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Autres médicaments de cette classe
Questions fréquentes
What is Avelumab used for?
Avelumab is a medicine in the class oncology. It is used for Renal cell carcinoma.
What side effects have been reported with Avelumab?
Fatigue, Nausea, Diarrhoea, Constipation, Decreased appetite, Infusion-related reactions.
Can Avelumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Limited data; based on mechanism it could cause foetal harm including abortion or stillbirth. Not recommended during pregnancy unless the woman's condition requires treatment. Breastfeeding: Unsafe. Unknown if excreted in human milk; advised not to breast-feed during treatment and for at least 1 month after the last dose.
What does Avelumab interact with?
MediHelp lists 5 known interactions for Avelumab. Moderate: 4 · Minor: 1. The most serious include Cefadroxil, Cefalexin, Piperacillin.
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