Référentiel des médicaments
Catumaxomab
Catumaxomab is a medicine in the class oncology.
- Classe médicamenteuse: Oncology
Dernière mise à jour Sources: EMA SmPC
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Oncology
- Code ATC
- L01FX03
- Noms commerciaux
- 1
- Pays et marchés
- 1
Mécanisme d'action
Trifunctional rat-mouse hybrid monoclonal antibody directed against EpCAM and CD3. A third binding site in the Fc region engages accessory immune cells via Fc-gamma receptors. This brings tumour cells, T-cells and accessory immune cells together and induces T-cell activation, T-cell killing, ADCC, CDC and phagocytosis.
Posologie adulte habituelle (résumé de la notice)
Malignant ascites with EpCAM-positive carcinomas: four intraperitoneal infusions of 10 micrograms on day 0, 20 micrograms on day 3, 50 micrograms on day 7 and 150 micrograms on day 10; overall treatment period should not exceed 21 days
Grossesse et allaitement
- Grossesse
- Unknown No or limited human data, and animal studies are insufficient. EU label: not recommended in pregnancy or in women who could become pregnant and are not using contraception.
- Allaitement
- Unknown Unknown whether it passes into milk; a risk to the infant cannot be excluded. EU label: decide whether to stop breastfeeding or the therapy. Given into the abdomen for malignant ascites.
Effets indésirables signalés
- Pyrexia
- Abdominal pain
- Nausea
- Vomiting
- Cytokine release syndrome
- Chills, fatigue, pain, diarrhoea, raised C-reactive protein
Contre-indications
- Hypersensitivity to the active substance or to any of the excipients.
- Hypersensitivity to murine (rat and/or mouse) proteins.
Précautions particulières
- Cytokine release symptoms can occur despite premedication, up to grade 4; patients should seek immediate medical attention.
- Systemic inflammatory response syndrome has been reported; patients should seek immediate medical attention if signs occur.
- Administration is not recommended in the presence of acute infections or other factors interfering with the immune system.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
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- Renal and hepatic dose adjustments
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- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Questions fréquentes
What is Catumaxomab used for?
Catumaxomab is a medicine in the class oncology.
What side effects have been reported with Catumaxomab?
Pyrexia, Abdominal pain, Nausea, Vomiting, Cytokine release syndrome, Chills, fatigue, pain, diarrhoea, raised C-reactive protein.
Can Catumaxomab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No or limited human data, and animal studies are insufficient. EU label: not recommended in pregnancy or in women who could become pregnant and are not using contraception. Breastfeeding: Unknown. Unknown whether it passes into milk; a risk to the infant cannot be excluded. EU label: decide whether to stop breastfeeding or the therapy. Given into the abdomen for malignant ascites.
What does Catumaxomab interact with?
MediHelp does not list a checked interaction for Catumaxomab yet. Always tell your pharmacist about every medicine you take.
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