Référentiel des médicaments
Cemiplimab
Cemiplimab is a medicine in the class oncology. It is used for non-small cell lung cancer.
- Classe médicamenteuse: Oncology
- Indications: non-small cell lung cancer
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Oncology
- Code ATC
- L01XC33
- Formes courantes
- injection
- Dosages courants
- 50 mg/ml
- Interactions connues
- 4 (Modérée: 3 · Mineure: 1)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Recombinant human IgG4 monoclonal antibody that binds PD-1 and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including the anti-tumor immune response.
Posologie adulte habituelle (résumé de la notice)
Metastatic or locally advanced CSCC: 350 mg IV infusion over 30 minutes every 3 weeks until disease progression, unacceptable toxicity, or up to 24 months
Grossesse et allaitement
- Grossesse
- Unsafe Can cause fetal harm: PD-1 blockade can disrupt immune tolerance to the fetus and raise the risk of pregnancy loss; IgG4 crosses the placenta. Check pregnancy status; use effective contraception during treatment and for at least 4 months after the last dose.
- Allaitement
- Unsafe No data on milk levels. Do not breastfeed during treatment and for at least 4 months after the last dose.
Effets indésirables signalés
- Fatigue
- Musculoskeletal pain
- Rash
- Diarrhea
- Anemia
- Pruritus
Contre-indications
- None.
Précautions particulières
- Severe and fatal immune-mediated adverse reactions (pneumonitis, colitis, hepatitis, endocrinopathies, dermatologic reactions, nephritis, transplant rejection) can occur in any organ; evaluate liver enzymes, creatinine and thyroid function at baseline and periodically.
- Infusion-related reactions: interrupt, slow infusion, or permanently discontinue based on severity.
- Fatal and other serious complications can occur in patients receiving allogeneic HSCT before or after PD-1/PD-L1 blocking antibody.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (4)
- Cemiplimab + Piperacillin Moderate
- Cemiplimab + Piperacillin-tazobactam Moderate
- Cemiplimab + Siponimod Moderate
- Cemiplimab + Penicillin g Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
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- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Questions fréquentes
What is Cemiplimab used for?
Cemiplimab is a medicine in the class oncology. It is used for Non-small cell lung cancer, Squamous cell carcinoma.
What side effects have been reported with Cemiplimab?
Fatigue, Musculoskeletal pain, Rash, Diarrhea, Anemia, Pruritus.
Can Cemiplimab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: PD-1 blockade can disrupt immune tolerance to the fetus and raise the risk of pregnancy loss; IgG4 crosses the placenta. Check pregnancy status; use effective contraception during treatment and for at least 4 months after the last dose. Breastfeeding: Unsafe. No data on milk levels. Do not breastfeed during treatment and for at least 4 months after the last dose.
What does Cemiplimab interact with?
MediHelp lists 4 known interactions for Cemiplimab. Moderate: 3 · Minor: 1. The most serious include Piperacillin, Piperacillin-tazobactam, Siponimod.
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