Interactions médicamenteuses
Cefepime + Plazomicin
Gravité: Modérée
Cefepime and Plazomicin: moderate interaction.
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Résumé
Plazomicin is an aminoglycoside with known nephrotoxicity, ototoxicity and neuromuscular blockade risk, and both drugs depend on renal elimination. Combining with cefepime may add to renal stress, and any decline in kidney function would increase plazomicin exposure and cefepime-related neurotoxicity.
Ce que signifie cette interaction, en termes simples
Cefepime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefepime belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Pourquoi elle survient
Additive potential nephrotoxicity with reduced renal clearance of both drugs if kidney injury occurs.
Conduite à tenir
Monitor serum creatinine and plazomicin concentrations per labeling, and adjust doses of both drugs to renal function. Assess hearing and neurologic status during therapy.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefepime
- Amikacin + Cefepime Modérée
- Cefepime + Cholera vaccine Modérée
- Cefepime + Dexamethasone-tobramycin Modérée
- Cefepime + Gentamicin Modérée
- Cefepime + Kanamycin Modérée
- Cefepime + Microbiota Modérée
Autres interactions de Plazomicin
- Cefaclor + Plazomicin Modérée
- Cefadroxil + Plazomicin Modérée
- Cefalexin + Plazomicin Modérée
- Cefazolin + Plazomicin Modérée
- Cefditoren + Plazomicin Modérée
- Cefixime + Plazomicin Modérée
Questions fréquentes
Can I take Cefepime with Plazomicin?
MediHelp rates the interaction as moderate. Cefepime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin is an aminoglycoside with known nephrotoxicity, ototoxicity and neuromuscular blockade risk, and both drugs depend on renal elimination. Combining with cefepime may add to renal stress, and any decline in kidney function would increase plazomicin exposure and cefepime-related neurotoxicity.
How serious is the interaction between Cefepime and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin concentrations per labeling, and adjust doses of both drugs to renal function. Assess hearing and neurologic status during therapy.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
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