Référentiel des médicaments
Darbepoetin alfa
Darbepoetin alfa is a medicine in the class miscellaneous. It is used for anemia.
- Classe médicamenteuse: Miscellaneous
- Indications: anemia
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Code ATC
- B03XA02
- Formes courantes
- injection
- Dosages courants
- 10 mcg, 20 mcg, 30 mcg
- Noms commerciaux
- 36
- Pays et marchés
- 5
Indications
Mécanisme d'action
Recombinant human erythropoietin with sialic acid additions to enhance stability; stimulates erythropoiesis via division & differentation of progenitor cells in bone marrow to induce the release of reticulocytes from the bone marrow into the bloodstream to become erythrocytes.
Posologie adulte habituelle (résumé de la notice)
Chronic Kidney Disease-Associated Anemia: Recommended starting dose: 0.45 mcg/kg IV/SC q4weeks
Grossesse et allaitement
- Grossesse
- Unknown Limited human data are insufficient to assess risk. In animals it increased early pregnancy loss at doses near the usual starting doses. Weigh the benefit to the mother (e.g. anaemia of kidney disease) against possible fetal risk; use only if needed.
- Allaitement
- Safe No milk data. It behaves like natural erythropoietin, which is normally present in milk, and as a large protein it is poorly absorbed by the infant; newborns have been given far larger doses directly. No special precautions are needed.
Effets indésirables signalés
- Headache
- Fatigue
- Diarrhea
- Dizziness
- Edema
- Arthralgia
Précautions particulières
- Hypertensive encephalopathy and seizures reported in patients with CKD
- Decrease dose if Hgb increase exceeds 1 g/dL in any 2 wk period
- If severe anemia and low reticulocyte count develop during treatment, withhold therapy and evaluate for pure red cell aplasia
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Darbepoetin alfa used for?
Darbepoetin alfa is a medicine in the class miscellaneous. It is used for Anemia.
What side effects have been reported with Darbepoetin alfa?
Headache, Fatigue, Diarrhea, Dizziness, Edema, Arthralgia.
Can Darbepoetin alfa be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data are insufficient to assess risk. In animals it increased early pregnancy loss at doses near the usual starting doses. Weigh the benefit to the mother (e.g. anaemia of kidney disease) against possible fetal risk; use only if needed. Breastfeeding: Safe. No milk data. It behaves like natural erythropoietin, which is normally present in milk, and as a large protein it is poorly absorbed by the infant; newborns have been given far larger doses directly. No special precautions are needed.
What does Darbepoetin alfa interact with?
MediHelp does not list a checked interaction for Darbepoetin alfa yet. Always tell your pharmacist about every medicine you take.
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