Référentiel des médicaments
Eflapegrastim
Eflapegrastim is a medicine in the class miscellaneous. It is used for febrile neutropenia.
- Classe médicamenteuse: Miscellaneous
- Indications: febrile neutropenia
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Formes courantes
- injection
- Dosages courants
- 13.2 mg/.6 ml
- Noms commerciaux
- 1
- Pays et marchés
- 1
Indications
Mécanisme d'action
Recombinant human granulocyte growth factor that binds G-CSF receptors on myeloid progenitor cells and neutrophils, triggering signaling that controls differentiation, proliferation, migration and survival.
Posologie adulte habituelle (résumé de la notice)
Decrease incidence of febrile neutropenia in non-myeloid malignancies on myelosuppressive chemotherapy: 13.2 mg, subcutaneous, once per chemotherapy cycle, approximately 24 hours after cytotoxic chemotherapy; do not give from 14 days before to 24 hours after chemotherapy
Grossesse et allaitement
- Grossesse
- Unknown No human data on Rolvedon; other rhG-CSF products showed no identified drug-associated risk in published studies. In rabbits, embryofetal lethality and reduced fetal weight occurred at approximately 6 times clinical exposure.
- Allaitement
- Unknown No data on presence in human milk; other rhG-CSF products are present at low levels. Consider breastfeeding benefits along with maternal clinical need.
Effets indésirables signalés
- Fatigue
- Nausea
- Diarrhea
- Bone pain
- Headache
- Pyrexia
Contre-indications
- History of serious allergic reactions to eflapegrastim, pegfilgrastim, or filgrastim products (may include anaphylaxis).
Précautions particulières
- Splenic rupture, including fatal cases; evaluate for enlarged spleen if left upper abdominal or shoulder pain.
- ARDS: evaluate patients with fever, lung infiltrates or respiratory distress; discontinue if ARDS.
- Serious allergic reactions including anaphylaxis: permanently discontinue.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
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Questions fréquentes
What is Eflapegrastim used for?
Eflapegrastim is a medicine in the class miscellaneous. It is used for Febrile neutropenia.
What side effects have been reported with Eflapegrastim?
Fatigue, Nausea, Diarrhea, Bone pain, Headache, Pyrexia.
Can Eflapegrastim be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data on Rolvedon; other rhG-CSF products showed no identified drug-associated risk in published studies. In rabbits, embryofetal lethality and reduced fetal weight occurred at approximately 6 times clinical exposure. Breastfeeding: Unknown. No data on presence in human milk; other rhG-CSF products are present at low levels. Consider breastfeeding benefits along with maternal clinical need.
What does Eflapegrastim interact with?
MediHelp does not list a checked interaction for Eflapegrastim yet. Always tell your pharmacist about every medicine you take.
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