Référentiel des médicaments
Glatiramer
Glatiramer is a medicine in the class central nervous system. It is used for multiple sclerosis.
- Classe médicamenteuse: Central Nervous System
- Indications: multiple sclerosis
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Central Nervous System
- Formes courantes
- injection
- Dosages courants
- 20 mg/ml, 40 mg/ml
- Interactions connues
- 18 (Mineure: 18)
- Noms commerciaux
- 4
- Pays et marchés
- 2
Indications
Mécanisme d'action
Mechanism in MS is not fully understood; thought to act by modifying immune processes believed responsible for MS pathogenesis. Animal and in vitro studies suggest induction and activation of glatiramer acetate-specific suppressor T-cells in the periphery.
Posologie adulte habituelle (résumé de la notice)
Relapsing forms of multiple sclerosis: Glatopa 20 mg per mL, subcutaneous, once per day
Grossesse et allaitement
- Grossesse
- Unknown Pharmacovigilance and observational data have not identified a drug-associated risk of major birth defects, miscarriage, or adverse outcomes; no adverse effects in rats or rabbits.
- Allaitement
- Unknown No data on presence in human milk; low systemic exposure means clinically relevant infant exposure is not expected. Weigh benefits of breastfeeding against maternal need.
Effets indésirables signalés
- Injection site erythema
- Injection site pain
- Injection site pruritus
- Injection site mass
- Vasodilatation
- Rash
Mises en garde encadrées
- Life-threatening and fatal anaphylaxis has been reported, and can occur at any time after starting therapy, from after the first dose to years later. Make patients aware of symptoms, which may overlap with immediate post-injection reaction, and instruct them to seek immediate medical care. Contraindicated in patients with prior hypersensitivity, including anaphylaxis. If anaphylaxis occurs, discontinue immediately and permanently unless a clear alternative etiology is identified.
Contre-indications
- Known hypersensitivity to glatiramer acetate or mannitol; reactions have included anaphylaxis.
Précautions particulières
- Immediate post-injection reaction (flushing, chest pain, palpitations, tachycardia, anxiety, dyspnea, throat constriction, urticaria) may occur within seconds to minutes after injection; usually transient.
- Transient chest pain may occur, often unrelated to injection.
- Lipoatrophy and rarely skin necrosis may occur at injection sites; lipoatrophy is thought to be permanent. Use proper technique and rotate sites.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (18)
- Anakinra + Glatiramer Minor
- Anti-thymocyte + Glatiramer Minor
- Basiliximab + Glatiramer Minor
- Denosumab + Glatiramer Minor
- Echinacea + Glatiramer Minor
- Etanercept + Glatiramer Minor
- Glatiramer + Golimumab Minor
- Glatiramer + Hepatitis A vaccine inactivated Minor
- Glatiramer + Human papillomavirus vaccine Minor
- Glatiramer + Leflunomide Minor
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Questions fréquentes
What is Glatiramer used for?
Glatiramer is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Glatiramer?
Injection site erythema, Injection site pain, Injection site pruritus, Injection site mass, Vasodilatation, Rash. Serious warning: Life-threatening and fatal anaphylaxis has been reported, and can occur at any time after starting therapy, from after the first dose to years later.
Can Glatiramer be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Pharmacovigilance and observational data have not identified a drug-associated risk of major birth defects, miscarriage, or adverse outcomes; no adverse effects in rats or rabbits. Breastfeeding: Unknown. No data on presence in human milk; low systemic exposure means clinically relevant infant exposure is not expected. Weigh benefits of breastfeeding against maternal need.
What does Glatiramer interact with?
MediHelp lists 18 known interactions for Glatiramer. Minor: 18. The most serious include Anakinra, Anti-thymocyte, Basiliximab.
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