Référentiel des médicaments
Dimethyl fumarate
Dimethyl fumarate is a medicine in the class central nervous system. It is used for multiple sclerosis.
- Classe médicamenteuse: Central Nervous System
- Indications: multiple sclerosis
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Central Nervous System
- Code ATC
- L04AX07
- Formes courantes
- gélule
- Dosages courants
- 120 mg, 240 mg
- Interactions connues
- 1 (Contre-indiquée: 1)
- Noms commerciaux
- 24
- Pays et marchés
- 5
Indications
Mécanisme d'action
Exact mechanism is unknown Methyl ester of fumaric acid that elicits immunomodulatory effects Dimethyl fumarate and the metabolite (monomethyl fumarate [MMF]) activates the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, a transcription factor encoded by the NFE2L2 gene
Posologie adulte habituelle (résumé de la notice)
120 mg PO BID initially; after 7 days, increase to maintenance dose of 240 mg BID
Grossesse et allaitement
- Grossesse
- Unknown Registry data (over 360 births) show no rise in birth defects or miscarriage; animal studies showed reproductive toxicity. EU label: use in pregnancy only if clearly needed. It is short-acting and is often stopped when pregnancy is planned or confirmed.
- Allaitement
- Safe Its active form (monomethyl fumarate) reaches milk in low amounts; data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. EU label: weigh breastfeeding against treatment. Monitor infant weight gain.
Effets indésirables signalés
- Vomiting
- Diarrhea
- Nausea
- Abdominal pain
- Rash
- Pruritus
Précautions particulières
- Progressive multifocal leukoencephalopathy (PML) resulting in death, in the postmarketing setting have occurred
- Do not restart therapy if anaphylaxis or angioedema occur
- Clinically significant cases of liver injury reported; onset ranged from a few days to several months after treatment initiation;
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (1)
- Dimethyl fumarate + Diroximel fumarate Contraindicated
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour ouvrir la monographie complète de Dimethyl fumarate : posologie, grossesse et allaitement, effets indésirables, mises en garde et toutes les interactions.
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Autres médicaments de cette classe
Questions fréquentes
What is Dimethyl fumarate used for?
Dimethyl fumarate is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Dimethyl fumarate?
Vomiting, Diarrhea, Nausea, Abdominal pain, Rash, Pruritus.
Can Dimethyl fumarate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Registry data (over 360 births) show no rise in birth defects or miscarriage; animal studies showed reproductive toxicity. EU label: use in pregnancy only if clearly needed. It is short-acting and is often stopped when pregnancy is planned or confirmed. Breastfeeding: Safe. Its active form (monomethyl fumarate) reaches milk in low amounts; data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. EU label: weigh breastfeeding against treatment. Monitor infant weight gain.
What does Dimethyl fumarate interact with?
MediHelp lists 1 known interactions for Dimethyl fumarate. Contraindicated: 1. The most serious include Diroximel fumarate.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
