Interactions médicamenteuses
Clorazepate + Orlistat
Gravité: Modérée
Clorazepate and Orlistat: moderate interaction.
Dernière mise à jour
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Résumé
Orlistat has been associated with reduced absorption of some antiepileptics and breakthrough seizures. Data for clorazepate are lacking, but loss of seizure control is the main concern.
Ce que signifie cette interaction, en termes simples
Clorazepate and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Orlistat belongs to Miscellaneous.
Pourquoi elle survient
Possible reduced intestinal absorption due to orlistat's inhibition of fat digestion.
Conduite à tenir
In patients with seizure disorders, monitor seizure frequency after orlistat initiation and consider separating doses by a few hours. Adjust clorazepate dose if control worsens.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contre-indiquée
- Clorazepate + Sodium oxybate Contre-indiquée
- Alfentanil + Clorazepate Majeure
- Alprazolam + Clorazepate Majeure
- Amobarbital + Clorazepate Majeure
- Belladonna and opium + Clorazepate Majeure
Autres interactions de Orlistat
- Cyclosporine + Orlistat Majeure
- Cyclosporin + Orlistat Majeure
- Orlistat + Triheptanoin Majeure
- Amiodarone + Orlistat Modérée
- Beta carotene + Orlistat Modérée
- Carbamazepine + Orlistat Modérée
Questions fréquentes
Can I take Clorazepate with Orlistat?
MediHelp rates the interaction as moderate. Clorazepate and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat has been associated with reduced absorption of some antiepileptics and breakthrough seizures. Data for clorazepate are lacking, but loss of seizure control is the main concern.
How serious is the interaction between Clorazepate and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients with seizure disorders, monitor seizure frequency after orlistat initiation and consider separating doses by a few hours. Adjust clorazepate dose if control worsens.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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