Référentiel des médicaments
Zidovudine
Zidovudine is a medicine in the class anti virals. It is used for hiv.
- Classe médicamenteuse: Anti Virals
- Indications: hiv
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Anti Virals
- Formes courantes
- gélule, comprimé, solution, injection
- Dosages courants
- 50 mg, 50 mg/5 ml, 100 mg
- Interactions connues
- 84 (Contre-indiquée: 2 · Majeure: 18 · Modérée: 39 · Mineure: 25)
- Noms commerciaux
- 5
- Pays et marchés
- 4
Indications
Mécanisme d'action
Inhibits thymidine kinase, Nucleoside Reverse Transcriptase Inhibitor (NRTI), Use with 3TC inhibits resistance
Posologie adulte habituelle (résumé de la notice)
HIV Infection Treatment: 300 mg PO q12hr OR 200 mg PO q8hr (600 mg/day)
Grossesse et allaitement
- Grossesse
- Safe Large registry data show no rise in birth defects. Long used to prevent mother-to-child HIV transmission, including IV during labour in some women. Transient raised lactate has been reported in exposed infants, without proven harm. Continue as prescribed in an HIV regimen.
- Allaitement
- Safe LactMed: well studied; low milk levels, most breastfed infants have undetectable blood levels, but some developed anaemia. US label: do not breastfeed (HIV). US/WHO guidance: with a sustained undetectable viral load, breastfeeding can be supported after counselling; otherwise formula or donor milk.
Effets indésirables signalés
- Diarrhea
- Anorexia
- Anemia
- Fever
- Granulocytopenia
Précautions particulières
- Risk of severe anemia and bone marrow depression; use with caution in patients with bone marrow compromise; hemoglobin reduction may occur 2-4 weeks
- Myopathy and myositis with pathological changes, similar to that produced by HIV-1 disease,associated with prolonged use of therapy
- Exacerbation of anemia due to ribavirin reported when zidovudine is part of HIV regimen; coadministration of ribavirin and zidovudine is not advised
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (84)
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
- Clozapine + Zidovudine Major
- Deferiprone + Zidovudine Major
- Doxorubicin + Zidovudine Major
- Elivaldogene autotemcel + Zidovudine Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
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- Pharmacokinetics
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- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Zidovudine used for?
Zidovudine is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Zidovudine?
Diarrhea, Anorexia, Anemia, Fever, Granulocytopenia.
Can Zidovudine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Large registry data show no rise in birth defects. Long used to prevent mother-to-child HIV transmission, including IV during labour in some women. Transient raised lactate has been reported in exposed infants, without proven harm. Continue as prescribed in an HIV regimen. Breastfeeding: Safe. LactMed: well studied; low milk levels, most breastfed infants have undetectable blood levels, but some developed anaemia. US label: do not breastfeed (HIV). US/WHO guidance: with a sustained undetectable viral load, breastfeeding can be supported after counselling; otherwise formula or donor milk.
What does Zidovudine interact with?
MediHelp lists 84 known interactions for Zidovudine. Contraindicated: 2 · Major: 18 · Moderate: 39 · Minor: 25. The most serious include Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel.
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