Interactions médicamenteuses
Deferiprone + Zidovudine
Gravité: Majeure
Deferiprone and Zidovudine: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Both agents can cause neutropenia, and deferiprone carries a boxed warning for agranulocytosis. Together they increase the risk of severe neutropenia and infection.
Ce que signifie cette interaction, en termes simples
Deferiprone and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Zidovudine belongs to Anti Virals.
Pourquoi elle survient
Additive myelosuppressive effects on neutrophil production.
Conduite à tenir
Avoid combining where possible, using an alternative antiretroviral. If unavoidable, monitor the absolute neutrophil count more frequently and interrupt deferiprone if neutropenia occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Deferiprone et Zidovudine, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Autres interactions de Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contre-indiquée
- Stavudine + Zidovudine Contre-indiquée
- Atidarsagene autotemcel + Zidovudine Majeure
- Betibeglogene autotemcel + Zidovudine Majeure
- Carboplatin + Zidovudine Majeure
- Cisplatin + Zidovudine Majeure
Autres interactions de Deferiprone
- Clozapine + Deferiprone Contre-indiquée
- Abemaciclib + Deferiprone Majeure
- Acalabrutinib + Deferiprone Majeure
- Ado-trastuzumab emtansine + Deferiprone Majeure
- Ado-trastuzumab + Deferiprone Majeure
- Aldesleukin + Deferiprone Majeure
Questions fréquentes
Can I take Deferiprone with Zidovudine?
MediHelp rates the interaction as major. Deferiprone and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can cause neutropenia, and deferiprone carries a boxed warning for agranulocytosis. Together they increase the risk of severe neutropenia and infection.
How serious is the interaction between Deferiprone and Zidovudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, using an alternative antiretroviral. If unavoidable, monitor the absolute neutrophil count more frequently and interrupt deferiprone if neutropenia occurs.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
