Interactions médicamenteuses
Atidarsagene autotemcel + Zidovudine
Gravité: Majeure
Atidarsagene autotemcel and Zidovudine: major interaction.
Dernière mise à jour
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Résumé
Antiretrovirals can interfere with lentiviral vector transduction during manufacture of gene therapy products. Residual drug in collected cells may reduce the efficacy of the product.
Ce que signifie cette interaction, en termes simples
Atidarsagene autotemcel and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Zidovudine belongs to Anti Virals.
Pourquoi elle survient
Zidovudine inhibits reverse transcription, impairing lentiviral transduction of harvested cells.
Conduite à tenir
Stop zidovudine at least one month before mobilization and until apheresis is complete, using an alternative approach if HIV therapy is required.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contre-indiquée
- Stavudine + Zidovudine Contre-indiquée
- Betibeglogene autotemcel + Zidovudine Majeure
- Carboplatin + Zidovudine Majeure
- Cisplatin + Zidovudine Majeure
- Clozapine + Zidovudine Majeure
Autres interactions de Atidarsagene autotemcel
Questions fréquentes
Can I take Atidarsagene autotemcel with Zidovudine?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals can interfere with lentiviral vector transduction during manufacture of gene therapy products. Residual drug in collected cells may reduce the efficacy of the product.
How serious is the interaction between Atidarsagene autotemcel and Zidovudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop zidovudine at least one month before mobilization and until apheresis is complete, using an alternative approach if HIV therapy is required.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Betibeglogene autotemcel. The full list is on the Zidovudine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
