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Interactions médicamenteuses

Cisplatin + Zidovudine

Gravité: Majeure

Cisplatin and Zidovudine: major interaction.

Dernière mise à jour

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Résumé

Both agents can suppress the bone marrow, so the combination raises the risk of anemia and neutropenia. Cisplatin nephrotoxicity may also affect zidovudine clearance.

Ce que signifie cette interaction, en termes simples

Cisplatin and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cisplatin belongs to Oncology; Zidovudine belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive bone marrow suppression.

Conduite à tenir

Monitor full blood counts frequently and consider an alternative to zidovudine during chemotherapy. Reduce doses or provide growth factor support as needed.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cisplatin with Zidovudine?

MediHelp rates the interaction as major. Cisplatin and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can suppress the bone marrow, so the combination raises the risk of anemia and neutropenia. Cisplatin nephrotoxicity may also affect zidovudine clearance.

How serious is the interaction between Cisplatin and Zidovudine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor full blood counts frequently and consider an alternative to zidovudine during chemotherapy. Reduce doses or provide growth factor support as needed.

What other medicines interact with Zidovudine?

MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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