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Interactions médicamenteuses

Doxorubicin + Zidovudine

Gravité: Majeure

Doxorubicin and Zidovudine: major interaction.

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Résumé

Both drugs suppress the bone marrow, so their combination increases the risk of anemia and neutropenia. Doxorubicin may also reduce the phosphorylation of zidovudine to its active form, which could weaken antiviral effect.

Ce que signifie cette interaction, en termes simples

Doxorubicin and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Doxorubicin belongs to Oncology; Zidovudine belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive myelosuppression, and possible interference with intracellular activation of zidovudine.

Conduite à tenir

Monitor full blood counts closely and consider an alternative antiretroviral during doxorubicin therapy. Watch HIV RNA for loss of virological control.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Doxorubicin with Zidovudine?

MediHelp rates the interaction as major. Doxorubicin and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress the bone marrow, so their combination increases the risk of anemia and neutropenia. Doxorubicin may also reduce the phosphorylation of zidovudine to its active form, which could weaken antiviral effect.

How serious is the interaction between Doxorubicin and Zidovudine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor full blood counts closely and consider an alternative antiretroviral during doxorubicin therapy. Watch HIV RNA for loss of virological control.

What other medicines interact with Zidovudine?

MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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