Référentiel des médicaments
Zolbetuximab
Zolbetuximab is a medicine in the class oncology. It is used for gastric cancer.
- Classe médicamenteuse: Oncology
- Indications: gastric cancer
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Oncology
- Code ATC
- L01FX31
- Formes courantes
- injection
- Dosages courants
- 20 mg/ml
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Claudin 18.2-directed cytolytic antibody that depletes CLDN18.2-positive cells via antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).
Posologie adulte habituelle (résumé de la notice)
HER2-negative, CLDN18.2-positive gastric/GEJ adenocarcinoma (with fluoropyrimidine- and platinum-containing chemotherapy): first dose 800 mg/m2 IV, then 600 mg/m2 IV every 3 weeks or 400 mg/m2 IV every 2 weeks; continue until disease progression or unacceptable toxicity
Grossesse et allaitement
- Grossesse
- Unknown No human data. No embryo-fetal toxicity in mice at about 1.9 times human exposure, though it crossed the placenta. Labels: give only if the benefit outweighs the potential risk. It is given with fluoropyrimidine and platinum chemotherapy, which can harm the fetus.
- Allaitement
- Unsafe No milk data; as a large antibody little is expected in milk (LactMed). Because of possible serious reactions in the infant, US label: do not breastfeed during treatment and for 8 months after the last dose; EU label: breastfeeding not recommended during treatment.
Effets indésirables signalés
- Nausea
- Vomiting
- Fatigue
- Decreased appetite
- Diarrhea
- Peripheral sensory neuropathy
Précautions particulières
- Hypersensitivity reactions including serious anaphylaxis and serious and fatal infusion-related reactions; monitor during and for at least 2 hours after infusion.
- Severe nausea and vomiting: VYLOY is emetogenic; premedicate with antiemetics before each infusion and manage with antiemetics or fluid replacement.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Questions fréquentes
What is Zolbetuximab used for?
Zolbetuximab is a medicine in the class oncology. It is used for Gastric cancer.
What side effects have been reported with Zolbetuximab?
Nausea, Vomiting, Fatigue, Decreased appetite, Diarrhea, Peripheral sensory neuropathy.
Can Zolbetuximab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. No embryo-fetal toxicity in mice at about 1.9 times human exposure, though it crossed the placenta. Labels: give only if the benefit outweighs the potential risk. It is given with fluoropyrimidine and platinum chemotherapy, which can harm the fetus. Breastfeeding: Unsafe. No milk data; as a large antibody little is expected in milk (LactMed). Because of possible serious reactions in the infant, US label: do not breastfeed during treatment and for 8 months after the last dose; EU label: breastfeeding not recommended during treatment.
What does Zolbetuximab interact with?
MediHelp does not list a checked interaction for Zolbetuximab yet. Always tell your pharmacist about every medicine you take.
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