Drug interactions
Amikacin + Magnesium sulphate
Severity: Moderate
Amikacin and Magnesium sulphate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia. Magnesium sulfate also potentiates neuromuscular blockade, which aminoglycosides can cause, so combined use may increase the risk of respiratory muscle weakness.
What this interaction means in plain words
Amikacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Magnesium sulphate belongs to Cardiovascular.
Why it happens
Aminoglycoside tubular toxicity increases renal magnesium loss, and both agents impair neuromuscular transmission, producing additive effects.
What to do
Monitor serum magnesium and renal function, and watch for muscle weakness or respiratory depression, especially with parenteral magnesium. Replace magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium sulphate
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Magnesium sulphate?
MediHelp rates the interaction as moderate. Amikacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia. Magnesium sulfate also potentiates neuromuscular blockade, which aminoglycosides can cause, so combined use may increase the risk of respiratory muscle weakness.
How serious is the interaction between Amikacin and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and renal function, and watch for muscle weakness or respiratory depression, especially with parenteral magnesium. Replace magnesium as needed.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amphotericin b deoxycholate, Atracurium, Baloxavir marboxil. The full list is on the Magnesium sulphate page.
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