Interactions médicamenteuses
Gentamicin + Pancuronium
Gravité: Majeure
Gentamicin and Pancuronium: major interaction.
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Résumé
Gentamicin can augment and prolong neuromuscular blockade from pancuronium. This may cause delayed recovery, residual paralysis and respiratory depression after surgery.
Ce que signifie cette interaction, en termes simples
Gentamicin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gentamicin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
Pourquoi elle survient
Additive neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor blockade.
Conduite à tenir
Use quantitative neuromuscular monitoring and reduce pancuronium dose. Keep ventilatory support available until full recovery, and consider a non-aminoglycoside alternative.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Pancuronium
- Amikacin + Pancuronium Majeure
- Bacitracin-neomycin-polymyxin + Pancuronium Majeure
- Capreomycin + Pancuronium Majeure
- Clindamycin + Pancuronium Majeure
- Colistin + Pancuronium Majeure
- Dexamethasone-tobramycin + Pancuronium Majeure
Autres interactions de Gentamicin
- Cidofovir + Gentamicin Contre-indiquée
- Adefovir + Gentamicin Majeure
- Amikacin + Gentamicin Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Majeure
- Amphotericin b deoxycholate + Gentamicin Majeure
- Amphotericin b + Gentamicin Majeure
Questions fréquentes
Can I take Gentamicin with Pancuronium?
MediHelp rates the interaction as major. Gentamicin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gentamicin can augment and prolong neuromuscular blockade from pancuronium. This may cause delayed recovery, residual paralysis and respiratory depression after surgery.
How serious is the interaction between Gentamicin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use quantitative neuromuscular monitoring and reduce pancuronium dose. Keep ventilatory support available until full recovery, and consider a non-aminoglycoside alternative.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
