Interactions médicamenteuses
Amikacin + Zoledronic acid
Gravité: Modérée
Amikacin and Zoledronic acid: moderate interaction.
Dernière mise à jour
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Résumé
Both zoledronic acid and aminoglycosides can lower serum calcium and magnesium, and both are nephrotoxic. Combined use may cause additive hypocalcemia and renal impairment.
Ce que signifie cette interaction, en termes simples
Amikacin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Zoledronic acid belongs to Musculoskeletal.
Pourquoi elle survient
Additive hypocalcemia and hypomagnesemia, with overlapping nephrotoxicity from renal tubular injury.
Conduite à tenir
Monitor serum calcium, magnesium and creatinine, and replace electrolytes as needed; keep aminoglycoside exposure short and monitor drug levels.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Zoledronic acid
Autres interactions de Amikacin
- Amikacin + Cidofovir Contre-indiquée
- Adefovir + Amikacin Majeure
- Amikacin + Amphotericin b Majeure
- Amikacin + Amphotericin b deoxycholate Majeure
- Amikacin + Atracurium Majeure
- Amikacin + Bacitracin Majeure
Questions fréquentes
Can I take Amikacin with Zoledronic acid?
MediHelp rates the interaction as moderate. Amikacin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both zoledronic acid and aminoglycosides can lower serum calcium and magnesium, and both are nephrotoxic. Combined use may cause additive hypocalcemia and renal impairment.
How serious is the interaction between Amikacin and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, magnesium and creatinine, and replace electrolytes as needed; keep aminoglycoside exposure short and monitor drug levels.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Bumetanide, Dichlorphenamide, Ethacrynic acid. The full list is on the Zoledronic acid page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
