Interactions médicamenteuses
Gentamicin + Zoledronic acid
Gravité: Modérée
Gentamicin and Zoledronic acid: moderate interaction.
Dernière mise à jour
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Résumé
Aminoglycosides can cause renal magnesium and calcium wasting and are nephrotoxic. Combined with zoledronic acid, this may increase the risk of hypocalcemia and renal injury. Zoledronic acid labeling advises caution with nephrotoxic drugs.
Ce que signifie cette interaction, en termes simples
Gentamicin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Zoledronic acid belongs to Musculoskeletal.
Pourquoi elle survient
Additive calcium lowering and potential additive nephrotoxicity through aminoglycoside-induced renal electrolyte wasting.
Conduite à tenir
Monitor serum calcium, magnesium and creatinine regularly. Replace electrolytes as needed and limit aminoglycoside duration.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Zoledronic acid
Autres interactions de Gentamicin
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- Amikacin + Gentamicin Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Majeure
- Amphotericin b deoxycholate + Gentamicin Majeure
- Amphotericin b + Gentamicin Majeure
Questions fréquentes
Can I take Gentamicin with Zoledronic acid?
MediHelp rates the interaction as moderate. Gentamicin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can cause renal magnesium and calcium wasting and are nephrotoxic. Combined with zoledronic acid, this may increase the risk of hypocalcemia and renal injury. Zoledronic acid labeling advises caution with nephrotoxic drugs.
How serious is the interaction between Gentamicin and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, magnesium and creatinine regularly. Replace electrolytes as needed and limit aminoglycoside duration.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
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