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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Edoxaban + Ketorolac

Gravité: Contre-indiquée

Edoxaban and Ketorolac: contraindicated interaction.

Dernière mise à jour

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Résumé

Ketorolac impairs platelet function and damages gastric mucosa while edoxaban is an anticoagulant, so major bleeding risk is considerably increased. Ketorolac labeling contraindicates its use in patients at risk of bleeding and with anticoagulants.

Ce que signifie cette interaction, en termes simples

Edoxaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Edoxaban belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive hemostatic impairment from NSAID platelet inhibition and factor Xa inhibition.

Conduite à tenir

Avoid ketorolac with edoxaban and use a non-NSAID analgesic; if exposure occurs, monitor for bleeding and hemoglobin changes.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Edoxaban with Ketorolac?

MediHelp rates the interaction as contraindicated. Edoxaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac impairs platelet function and damages gastric mucosa while edoxaban is an anticoagulant, so major bleeding risk is considerably increased. Ketorolac labeling contraindicates its use in patients at risk of bleeding and with anticoagulants.

How serious is the interaction between Edoxaban and Ketorolac?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac with edoxaban and use a non-NSAID analgesic; if exposure occurs, monitor for bleeding and hemoglobin changes.

What other medicines interact with Ketorolac?

MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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