Interactions médicamenteuses
Apraclonidine + Phenelzine
Gravité: Majeure
Apraclonidine and Phenelzine: major interaction.
Dernière mise à jour
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Résumé
Apraclonidine labeling lists MAO inhibitors as a contraindication. MAOIs may interfere with catecholamine metabolism and alter blood pressure responses to the alpha-agonist, though systemic exposure from ophthalmic use is low.
Ce que signifie cette interaction, en termes simples
Apraclonidine and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apraclonidine belongs to Cardiovascular; Phenelzine belongs to Central Nervous System.
Pourquoi elle survient
Not well established; possible altered catecholamine handling due to MAO inhibition with an alpha-2 agonist.
Conduite à tenir
Avoid per labeling and choose another intraocular pressure-lowering agent. If unavoidable, monitor blood pressure.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Phenelzine
- 5-HTP + Phenelzine Contre-indiquée
- Amitriptyline + Phenelzine Contre-indiquée
- Amoxapine + Phenelzine Contre-indiquée
- Atomoxetine + Phenelzine Contre-indiquée
- Benzphetamine + Phenelzine Contre-indiquée
- Brimonidine + Phenelzine Contre-indiquée
Autres interactions de Apraclonidine
- Apraclonidine + Isocarboxazid Contre-indiquée
- Apraclonidine + Linezolid Majeure
- Apraclonidine + Rasagiline Majeure
- Apraclonidine + Selegiline Majeure
- Apraclonidine + Tranylcypromine Majeure
Questions fréquentes
Can I take Apraclonidine with Phenelzine?
MediHelp rates the interaction as major. Apraclonidine and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine labeling lists MAO inhibitors as a contraindication. MAOIs may interfere with catecholamine metabolism and alter blood pressure responses to the alpha-agonist, though systemic exposure from ophthalmic use is low.
How serious is the interaction between Apraclonidine and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid per labeling and choose another intraocular pressure-lowering agent. If unavoidable, monitor blood pressure.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
