Interactions médicamenteuses
Apraclonidine + Linezolid
Gravité: Majeure
Apraclonidine and Linezolid: major interaction.
Dernière mise à jour
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Résumé
Apraclonidine labeling contraindicates use with MAO inhibitors, and linezolid has MAO-inhibiting activity. Concern is for altered catecholamine handling and blood pressure changes, although ophthalmic systemic exposure is small.
Ce que signifie cette interaction, en termes simples
Apraclonidine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apraclonidine belongs to Cardiovascular; Linezolid belongs to Anti Bacterial.
Pourquoi elle survient
Mechanism not firmly established; likely MAO inhibition affecting adrenergic agonist disposition.
Conduite à tenir
Avoid concurrent use where possible, following the apraclonidine labeling. If both are needed, monitor blood pressure and heart rate.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Linezolid
- Amoxapine + Linezolid Contre-indiquée
- Atomoxetine + Linezolid Contre-indiquée
- Benzphetamine + Linezolid Contre-indiquée
- Brimonidine + Linezolid Contre-indiquée
- Bupropion-naltrexone + Linezolid Contre-indiquée
- Bupropion + Linezolid Contre-indiquée
Autres interactions de Apraclonidine
- Apraclonidine + Isocarboxazid Contre-indiquée
- Apraclonidine + Phenelzine Majeure
- Apraclonidine + Rasagiline Majeure
- Apraclonidine + Selegiline Majeure
- Apraclonidine + Tranylcypromine Majeure
Questions fréquentes
Can I take Apraclonidine with Linezolid?
MediHelp rates the interaction as major. Apraclonidine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine labeling contraindicates use with MAO inhibitors, and linezolid has MAO-inhibiting activity. Concern is for altered catecholamine handling and blood pressure changes, although ophthalmic systemic exposure is small.
How serious is the interaction between Apraclonidine and Linezolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, following the apraclonidine labeling. If both are needed, monitor blood pressure and heart rate.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
