Interactions médicamenteuses
Apraclonidine + Rasagiline
Gravité: Majeure
Apraclonidine and Rasagiline: major interaction.
Dernière mise à jour
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Résumé
Apraclonidine labeling advises against use in patients taking MAO inhibitors. Theoretically, MAO inhibition could alter catecholamine handling and cause blood pressure changes, though ophthalmic systemic exposure is small.
Ce que signifie cette interaction, en termes simples
Apraclonidine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apraclonidine belongs to Cardiovascular; Rasagiline belongs to Central Nervous System.
Pourquoi elle survient
Not firmly established; reduced catecholamine metabolism by MAO inhibition may potentiate the cardiovascular effects of the alpha-2 agonist.
Conduite à tenir
Avoid apraclonidine in patients on rasagiline and select another intraocular pressure agent. If unavoidable, monitor blood pressure and heart rate.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Rasagiline
- Atomoxetine + Rasagiline Contre-indiquée
- Brimonidine + Rasagiline Contre-indiquée
- Bupropion-naltrexone + Rasagiline Contre-indiquée
- Bupropion + Rasagiline Contre-indiquée
- Clomipramine + Rasagiline Contre-indiquée
- Desvenlafaxine + Rasagiline Contre-indiquée
Autres interactions de Apraclonidine
- Apraclonidine + Isocarboxazid Contre-indiquée
- Apraclonidine + Linezolid Majeure
- Apraclonidine + Phenelzine Majeure
- Apraclonidine + Selegiline Majeure
- Apraclonidine + Tranylcypromine Majeure
Questions fréquentes
Can I take Apraclonidine with Rasagiline?
MediHelp rates the interaction as major. Apraclonidine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine labeling advises against use in patients taking MAO inhibitors. Theoretically, MAO inhibition could alter catecholamine handling and cause blood pressure changes, though ophthalmic systemic exposure is small.
How serious is the interaction between Apraclonidine and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid apraclonidine in patients on rasagiline and select another intraocular pressure agent. If unavoidable, monitor blood pressure and heart rate.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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