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Interactions médicamenteuses

Apraclonidine + Selegiline

Gravité: Majeure

Apraclonidine and Selegiline: major interaction.

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Résumé

Apraclonidine is an alpha-2 agonist, and labeling advises against its use with MAO inhibitors because of a possible rise in blood pressure. The pharmacological basis is not fully clear, and exposure is low with ophthalmic use, but the labeling warning remains.

Ce que signifie cette interaction, en termes simples

Apraclonidine and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Apraclonidine belongs to Cardiovascular; Selegiline belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Mechanism is not established; possible altered catecholamine handling with MAO inhibition affecting blood pressure.

Conduite à tenir

Avoid the combination where possible and choose another ocular hypotensive agent. If apraclonidine is essential, monitor blood pressure closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apraclonidine with Selegiline?

MediHelp rates the interaction as major. Apraclonidine and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine is an alpha-2 agonist, and labeling advises against its use with MAO inhibitors because of a possible rise in blood pressure. The pharmacological basis is not fully clear, and exposure is low with ophthalmic use, but the labeling warning remains.

How serious is the interaction between Apraclonidine and Selegiline?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another ocular hypotensive agent. If apraclonidine is essential, monitor blood pressure closely.

What other medicines interact with Selegiline?

MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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