Interactions médicamenteuses
Aripiprazole + Mitotane
Gravité: Majeure
Aripiprazole and Mitotane: major interaction.
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Résumé
Mitotane is a strong CYP3A4 inducer and can substantially lower aripiprazole concentrations, risking loss of psychiatric control. The induction can persist for weeks after mitotane is stopped.
Ce que signifie cette interaction, en termes simples
Aripiprazole and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Mitotane belongs to Oncology.
Pourquoi elle survient
Induction of CYP3A4 increases aripiprazole clearance.
Conduite à tenir
Aripiprazole labeling advises roughly doubling the dose with strong CYP3A4 inducers; titrate by clinical response. Reduce the dose again if mitotane is discontinued.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Aripiprazole
- Aripiprazole + Pimozide Contre-indiquée
- Aripiprazole + Thioridazine Contre-indiquée
- Amisulpride + Aripiprazole Majeure
- Aripiprazole + Arsenic trioxide Majeure
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Majeure
- Aripiprazole + Carbamazepine Majeure
Autres interactions de Mitotane
- Doravirine + Mitotane Contre-indiquée
- Fostemsavir + Mitotane Contre-indiquée
- Lorlatinib + Mitotane Contre-indiquée
- Abiraterone + Mitotane Majeure
- Apixaban + Mitotane Majeure
- Aprepitant + Mitotane Majeure
Questions fréquentes
Can I take Aripiprazole with Mitotane?
MediHelp rates the interaction as major. Aripiprazole and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a strong CYP3A4 inducer and can substantially lower aripiprazole concentrations, risking loss of psychiatric control. The induction can persist for weeks after mitotane is stopped.
How serious is the interaction between Aripiprazole and Mitotane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Aripiprazole labeling advises roughly doubling the dose with strong CYP3A4 inducers; titrate by clinical response. Reduce the dose again if mitotane is discontinued.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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