Interactions médicamenteuses
Apixaban + Mitotane
Gravité: Majeure
Apixaban and Mitotane: major interaction.
Dernière mise à jour
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Résumé
Mitotane is a strong CYP3A4 inducer and can substantially lower apixaban concentrations, risking thrombosis or stroke from inadequate anticoagulation. The inducing effect persists for weeks after mitotane is stopped.
Ce que signifie cette interaction, en termes simples
Apixaban and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Mitotane belongs to Oncology.
Pourquoi elle survient
Induction of CYP3A4 (and likely P-gp) increases apixaban clearance.
Conduite à tenir
Avoid the combination and choose an alternative anticoagulant such as low-molecular-weight heparin or a vitamin K antagonist with INR monitoring.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Apixaban
- Apixaban + Dabigatran Contre-indiquée
- Apixaban + Defibrotide Contre-indiquée
- Apixaban + Edoxaban Contre-indiquée
- Apixaban + Ketorolac Contre-indiquée
- Apixaban + Mifepristone Contre-indiquée
- Abciximab + Apixaban Majeure
Autres interactions de Mitotane
- Doravirine + Mitotane Contre-indiquée
- Fostemsavir + Mitotane Contre-indiquée
- Lorlatinib + Mitotane Contre-indiquée
- Abiraterone + Mitotane Majeure
- Aprepitant + Mitotane Majeure
- Aripiprazole + Mitotane Majeure
Questions fréquentes
Can I take Apixaban with Mitotane?
MediHelp rates the interaction as major. Apixaban and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a strong CYP3A4 inducer and can substantially lower apixaban concentrations, risking thrombosis or stroke from inadequate anticoagulation. The inducing effect persists for weeks after mitotane is stopped.
How serious is the interaction between Apixaban and Mitotane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative anticoagulant such as low-molecular-weight heparin or a vitamin K antagonist with INR monitoring.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
