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Interactions médicamenteuses

Lorlatinib + Mitotane

Gravité: Contre-indiquée

Lorlatinib and Mitotane: contraindicated interaction.

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Résumé

Mitotane is a strong CYP3A4 inducer with a very long half-life, and can markedly lower lorlatinib exposure. This may lead to loss of efficacy and hepatotoxicity.

Ce que signifie cette interaction, en termes simples

Lorlatinib and Mitotane are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Lorlatinib belongs to Oncology; Mitotane belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Mitotane induces CYP3A4 and increases lorlatinib metabolism.

Conduite à tenir

Avoid the combination; because mitotane persists for weeks to months, choose an alternative to lorlatinib or other therapy.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Lorlatinib with Mitotane?

MediHelp rates the interaction as contraindicated. Lorlatinib and Mitotane are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mitotane is a strong CYP3A4 inducer with a very long half-life, and can markedly lower lorlatinib exposure. This may lead to loss of efficacy and hepatotoxicity.

How serious is the interaction between Lorlatinib and Mitotane?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; because mitotane persists for weeks to months, choose an alternative to lorlatinib or other therapy.

What other medicines interact with Lorlatinib?

MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.

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