Interactions médicamenteuses
Atidarsagene autotemcel + Pneumococcal vaccine 13-valent
Gravité: Modérée
Atidarsagene autotemcel and Pneumococcal vaccine 13-valent: moderate interaction.
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Résumé
Atidarsagene autotemcel involves myeloablative conditioning followed by hematologic reconstitution, during which immune responses to vaccines are unreliable. Vaccine safety and effectiveness around this therapy have not been studied. Vaccination close to conditioning may be ineffective and confound assessment of adverse events.
Ce que signifie cette interaction, en termes simples
Atidarsagene autotemcel and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atidarsagene autotemcel belongs to Miscellaneous; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Pourquoi elle survient
Myeloablative conditioning and hematopoietic reconstitution impair immune response to vaccination.
Conduite à tenir
Give age-appropriate vaccines, including pneumococcal, before conditioning (not within about 6 weeks before it). Defer vaccination until hematologic recovery after treatment.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Pneumococcal vaccine 13-valent
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Autres interactions de Atidarsagene autotemcel
Questions fréquentes
Can I take Atidarsagene autotemcel with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as moderate. Atidarsagene autotemcel and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atidarsagene autotemcel involves myeloablative conditioning followed by hematologic reconstitution, during which immune responses to vaccines are unreliable. Vaccine safety and effectiveness around this therapy have not been studied. Vaccination close to conditioning may be ineffective and confound assessment of adverse events.
How serious is the interaction between Atidarsagene autotemcel and Pneumococcal vaccine 13-valent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give age-appropriate vaccines, including pneumococcal, before conditioning (not within about 6 weeks before it). Defer vaccination until hematologic recovery after treatment.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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