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Interactions médicamenteuses

Atracurium + Oxytetracycline

Gravité: Modérée

Atracurium and Oxytetracycline: moderate interaction.

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Résumé

Tetracyclines have weak neuromuscular blocking effects, and potentiation of nondepolarising blockers is described mainly in case reports. Clinical significance with oxytetracycline is likely small but could prolong recovery.

Ce que signifie cette interaction, en termes simples

Atracurium and Oxytetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Atracurium belongs to Musculoskeletal; Oxytetracycline belongs to Anti Bacterial.

Niveau de preuve: Low

Pourquoi elle survient

Possible calcium chelation and weak presynaptic neuromuscular blockade adding to nondepolarising blockade.

Conduite à tenir

Monitor neuromuscular function with train-of-four during surgery or ICU use. Adjust atracurium dosing to response.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Atracurium with Oxytetracycline?

MediHelp rates the interaction as moderate. Atracurium and Oxytetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetracyclines have weak neuromuscular blocking effects, and potentiation of nondepolarising blockers is described mainly in case reports. Clinical significance with oxytetracycline is likely small but could prolong recovery.

How serious is the interaction between Atracurium and Oxytetracycline?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four during surgery or ICU use. Adjust atracurium dosing to response.

What other medicines interact with Atracurium?

MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.

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