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Interactions médicamenteuses

Bismuth subsalicylate + Oxytetracycline

Gravité: Modérée

Bismuth subsalicylate and Oxytetracycline: moderate interaction.

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Résumé

Bismuth in oral bismuth subsalicylate can bind oxytetracycline in the gut and reduce its absorption. This may lead to lower antibiotic levels and treatment failure.

Ce que signifie cette interaction, en termes simples

Bismuth subsalicylate and Oxytetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Bismuth subsalicylate belongs to Gastrointestinal Tract; Oxytetracycline belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Chelation of oxytetracycline by bismuth in the gastrointestinal tract reduces absorption.

Conduite à tenir

Separate doses by at least 2 to 3 hours, giving oxytetracycline first, or use an alternative if separation is not feasible.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bismuth subsalicylate with Oxytetracycline?

MediHelp rates the interaction as moderate. Bismuth subsalicylate and Oxytetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth in oral bismuth subsalicylate can bind oxytetracycline in the gut and reduce its absorption. This may lead to lower antibiotic levels and treatment failure.

How serious is the interaction between Bismuth subsalicylate and Oxytetracycline?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 to 3 hours, giving oxytetracycline first, or use an alternative if separation is not feasible.

What other medicines interact with Bismuth subsalicylate?

MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.

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