Interactions médicamenteuses
Avatrombopag + Mifepristone
Gravité: Modérée
Avatrombopag and Mifepristone: moderate interaction.
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Résumé
Mifepristone inhibits CYP3A4 and may increase avatrombopag exposure. This can enhance platelet count elevation and raise the risk of thromboembolic events.
Ce que signifie cette interaction, en termes simples
Avatrombopag and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Mifepristone belongs to Endocrine.
Pourquoi elle survient
Inhibition of CYP3A4 (with CYP2C9 contribution) metabolism of avatrombopag by mifepristone.
Conduite à tenir
Use a reduced avatrombopag starting dose when treating ITP, as per labeling. Monitor platelet counts and adjust the dose when mifepristone is started or stopped.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Mifepristone
- Apixaban + Mifepristone Contre-indiquée
- Argatroban + Mifepristone Contre-indiquée
- Cisapride + Mifepristone Contre-indiquée
- Cortisone + Mifepristone Contre-indiquée
- Cyclosporin + Mifepristone Contre-indiquée
- Dabigatran etexilate + Mifepristone Contre-indiquée
Autres interactions de Avatrombopag
- Amiodarone + Avatrombopag Modérée
- Amobarbital + Avatrombopag Modérée
- Avatrombopag + Bosentan Modérée
- Avatrombopag + Carbamazepine Modérée
- Avatrombopag + Enzalutamide Modérée
- Avatrombopag + Fluconazole Modérée
Questions fréquentes
Can I take Avatrombopag with Mifepristone?
MediHelp rates the interaction as moderate. Avatrombopag and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase avatrombopag exposure. This can enhance platelet count elevation and raise the risk of thromboembolic events.
How serious is the interaction between Avatrombopag and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced avatrombopag starting dose when treating ITP, as per labeling. Monitor platelet counts and adjust the dose when mifepristone is started or stopped.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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